Malaria Control During Mass Population Movements and Natural Disasters (2003) / Chapter Skim
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Appendix A: Description of Antimalarial Drugs
Appendix A: Description of Antimalarial Drugs
Pages 145-150
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From page 145... ...
Historically, it has been the drug of choice for the treatment of nonsevere or uncomplicated malaria and for chemoprophylaxis. Chloroquine acts primarily against erythrocytic asexual stages, although it has gametocidal properties.
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From page 146... ...
Concerns about sulfa drug use during pregnancy are outweighed by the known risks to mother and fetus of untreated malaria. Finally, use of folate supplementation concurrently with antifol antimalarials may increase the frequency of treatment failure (van Hensbroek et al., 19951.
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From page 147... ...
deficiencies can experience severe and potentially fatal hemolytic anemia if treated with primaquine. The most severe Mediterranean B variant and related Asian variants of G6PD deficiency can occur at high rates among some groups and in some regions; Kurdish Jews (62 percent)
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From page 148... ...
A subsequent study suggests that cardiac abnormalities are dose dependent and can be severe in patients with preexisting cardiopathy; the authors suggest that electrocardiography be conducted on all patients prior to treatment with halofantrine (Monlun et al., 19951. A micronized formulation has improved halofantrine's poor oral bioavailability; however, it should be given on an empty stomach.
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From page 149... ...
Preliminary results of studies to determine if this faster action produces improved survival suggest that there is quicker improvement of coma following treatment with artemisinins (Taylor et al., 1993; Salako et al., 19941. When used alone, especially for durations of less than 5 to 7 days, recrudescence rates are high.
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From page 150... ...
. Although there is some concern about resistance developing rapidly to this combination, Malarone currently appears to be highly effective against most drug-resistant malaria parasites.
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