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Malaria Control During Mass Population Movements and Natural Disasters (2003) / Chapter Skim
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Appendix B: Methodology for Efficacy Assessment of In Vivo Malaria Therapy
Pages 151-154

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From page 151...
... Those who have a parasite density above a defined level are treated with a standard dose of antimalarial drug under supervision to ensure compliance. Follow-up thick blood smears are typically obtained on days 2 and 3, 7 days after initiation of treatment, and then once every 7 days for the duration of follow-up.
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From page 152...
... The World Health Organization has defined standard definitions for both parasitological failure and clinical failure. The definitions differ somewhat for areas with high transmission, with differences in the protocol highlighted for areas of low/moderate transmission.
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From page 153...
... RI denotes a mildly resistant response in which parasitemia declines substantially within the first 48 to 72 hours posttreatment, is apparently cleared on subsequent examinations, but recrudesces sometime during follow-up. S denotes a fully sensitive response in which parasites are cleared and patients remain parasite free for the duration of follow-up.
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From page 154...
... 25 percent of the Day 0 density AND negative blood smears on every follow-up examination between Day 7 and Day 14. With follow-up periods of 14 days, it is not possible to distinguish sensitive responses from late recrudescences, and these responses are combined in the RI/S category.
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Key Terms

  • blood smear
  • parasitological response
  • resistant response
  • parasitological failure
  • positive day

  • clinical failure
  • hours posttreatment
  • standard dose
  • blood smears
  • late clinical

  • antimalarial drug
  • previously meeting
  • parasite free
  • positive blood
  • thick blood

  • drug efficacy
  • previous versions
  • remain parasite
  • negative day
  • rii denotes

  • actual clearance
  • ensure compliance
  • defined standard
  • classify parasitological
  • parasitemia declines

  • patient continues
  • patients remain
  • subsequent examinations
  • severely resistant
  • moderately resistant


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