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Self-Perpetuating Structural States in Biology, Disease, and Genetics (2002) / Chapter Skim
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Self-perpetuating structural states in biology, disease, and genetics
Pages 1-1

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... t and Steven Henikoff$ * Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142; and tThe Fred Hutchinson Cancer Research Center, Seattle, WA 98109 Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions.
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Key Terms

  • histone tail
  • chromatin inheritance
  • chromatin states
  • sackler colloquium
  • protein conformation

  • colloquium entitled
  • held march
  • protein conformations
  • macromolecular interactions
  • posttranslational modifications

  • foster interactions
  • resembling amyloid
  • chromatin field
  • hutchinson cancer
  • cellular machinery

  • participants described
  • nonhistone structural
  • dna methylation
  • conformation leads
  • structural proteins

  • dna inheritance
  • alternative protein
  • constitute chromatin
  • distinct chromatin
  • residue underlies

  • continuing refinements
  • maintain distinct
  • single modification
  • fundamental mechanisms
  • rna makes


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