Advancing Prion Science Guidance for the National Prion Research Program (2004) / Chapter Skim
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Executive Summary
Executive Summary
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To develop any of these tools to protect human and animal health, the committee determined, the scientific community must first answer fundamental questions about TSEs and priors. Therefore, the committee recommends that NPRP fund basic biomedical research on the structural features of priors; the molecular mechanisms of prion replication; the mechanisms of TSE pathogenesis; and the physiological function of prion protein, the normal form of the misfolded protein of priors.
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Therefore, the committee recommends that NPRP support research to determine the risk of prion transmission through human blood. The outbreak of the TSE called bovine spongiform encephalopathy (BSE)
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Finally, the committee highlights the potentially damaging economic effects of the discovery of even a single case of BSE in the United States. Studies evaluating the human risks associated with the infectious agent of CWD should also be funded, the committee recommends.
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