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Advancing Prion Science Guidance for the National Prion Research Program (2004) / Chapter Skim
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8 Infrastructure for Research on Transmissible Spongiform Encephalopathies
Pages 214-222

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From page 214...
... At present fewer than 20 principal investigators conduct TSE research funded by the National Institutes of Health (NIH) , the largest sponsor of TSE research in the United States.
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From page 215...
... scientists are involved in TSE research for a number of reasons, including but not limited to the paucity of available funds. First, the small number of TSE research laboratories in the United States limits the number of opportunities to obtain training, experience, and expertise especially for new investigators.
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From page 216...
... Recommendation 8.3: Provide funds to develop scientifically based biological safety level standards for laboratories conducting research that involves infectious agents known to cause transmissible spongiform encephalopathies. [Priority 21 iThe committee denotes each recommendation as priority level 1, 2, or 3 based on the criteria and process described in the Introduction.
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From page 217...
... Therefore, there needs to be a mechanism in the United States for giving investigators access to research reference standards. Reference Repositories NIH sponsored a meeting in February 2002 to establish a TSE reagent repository.
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From page 218...
... Johnson, The Johns Hopkins University, 20021. The TSE research community in the United States needs not only standard reference materials but also reference centers.
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From page 219...
... A small, albeit dedicated, effort is proceeding in the United States, and that effort will continue to make contributions, but at a pace that ultimately may not accomplish the nation's goals in a timely manner. To accomplish the broad goals cited at the beginning in this chapter, the capacity to conduct TSE research must be enhanced significantly.
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From page 220...
... France has a BSL 3 facility that can house 60 macaques, and the government is building a dedicated prion research facility that will house 120 monkeys and provide laboratories for visiting scientists (personal communication, R.T. Johnson, The Johns Hopkins University, 2002~.
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From page 221...
... Masters, University of Melbourne, May 4, 20031. The United States could foster international collaboration by sponsoring one or a series of international conferences on advancements in prion science.
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From page 222...
... Geneva: World Health Organization Communicable Disease Surveillance Control and Office International des Epizooties.
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Key Terms

  • transmissible spongiform
  • prion research
  • spongiform encephalopathies
  • tse investigators
  • laboratories conducting

  • biological safety
  • prion science
  • reference materials
  • tse reagent
  • reagent repository

  • conduct tse
  • safety levels
  • provide funds
  • spongiform encephalopathy
  • safety level

  • relevant science
  • european union
  • research facility
  • conducting tse
  • conducting prion

  • european laboratories
  • bovine spongiform
  • standardized reagents
  • engineered animals
  • european commission

  • international collaboration
  • prion diseases
  • action plan
  • million dollars
  • goals cited


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