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Advancing Prion Science Guidance for the National Prion Research Program (2004) / Chapter Skim
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Pages 259-262

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 259...
... The segments with nonregular secondary structure within the C-te'lllinal domain are yellow. Yellow dots represent the flexibly disordered tail composed of residues 23-121.
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From page 260...
... SOURCES: electron micrograph: H Wille, Institute for Neurodegenerative Diseases, University of California, San Francisco, July 2003; models: C
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From page 261...
... Bottom row: The IHC technique used on these tissues stains PrP brown and removes PrPC, hence the absence of staining in normal tissue. The fine, ubiquitous brown stain in sCID tissue indicates a fairly even distribution of PrPSC, whereas the spotty, intense brown stains in vCJD tissue reflect an uneven distribution of the protein, whichhas accumulated in plaques.
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From page 262...
... U, ~ ~ 8 ~ .= JO — o au _c o TO a (~, cat cO o ~ ~ · - ~ .o ~ 11 ha ~ a' ¢ ~ ^~ in C_a Cal I, ~ 11 Hi; ~ Aim ~ ~ ·m An ~ au US .
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Key Terms

  • ihc technique
  • human brain
  • mainly clustered
  • bottom row
  • intense brown

  • brown stain
  • national cid
  • daisy plaques
  • called florid
  • cid surveillance

  • normal tissue
  • top row
  • models scaled
  • polypeptide models
  • disordered tail

  • scid tissue
  • tissue indicates
  • presumed structure
  • vcjd tissue
  • uneven distribution

  • removes prpc
  • neurodegenerative diseases
  • whichhas accumulated
  • commonly called
  • prion disease

  • normal brain
  • disease pathology
  • national prion
  • neurodegeneration described
  • tail composed


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