Regenerative Medicine (2003) / Chapter Skim
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7 Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver
7 Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver
Pages 34-37
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From page 34... ...
Fixed liver slices were washed with PBS, cryoprotected by incubation in This paper results from the Arthur M Sackier Colioqulum of the Nationai Acaclemy of Sciences, "Regenerative Meclicine," heicl October 18-22, 2002, at the Arnoicl ancl Mabei Beckman Center of the Nationai Academies of Science ancl Engineering in Irvine, CA.
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From page 35... ...
Immunof luorescence analysis was performed by using a DeltaVision restoration microscopy system (Applied Precision, Issaquah, WA) consisting of an Olympus IX70 microscope equipped with HBO100 epiillumination source.
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From page 36... ...
In the BM reconstituted model, donor BM-derived hematological cells are continuously supplied, circulate in the recipient liver, and have a lifelong chance to compete with endogenous defective hepatocytes. Our data show that even with this continuous chance BMCs failed to repopulate the diseased liver in the TgN(AlblHBV)
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From page 37... ...
FEBS Lett.
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