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Regenerative Medicine (2003) / Chapter Skim
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11 Indian hedgehog and B-catenin signaling: Role in the sebaceous lineage of normal and neoplastic mammalian epidermis
Pages 57-64

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From page 57...
... Thus, whereas basal cell carcinomas (BCCs) may reflect the relatively undifferentiated phenotype of the hair follicle outer root sheath, squamous cell carcinomas exhibit elements of IFE differentiation, sebaceous tumors contain terminally differentiated sebocytes, and pilomatricomas and trichofolliculomas contain cells undergoing differentiation along hair lineages (44.
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From page 58...
... The sections were then treated with 10 mM citrate buffer at 97°C for 30 min. Sections were incubated overnight at 4°C with diluted rabbit polyclonal antibodies directed against human PTCH1 (Research Genetics, Huntsville, AL, and Santa Cruz Biotechnology, sc-6149, both 1:200)
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From page 59...
... under control of the keratin 14 promoter develop spontaneous skin tumors (10~. The majority of the tumors are sebaceous adenomas, consisting of differentiated sebocytes surrounded by undifferentiated progenitor cells.
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From page 60...
... 3~. In both human and mouse skin, IHH protein was strongly expressed in the differentiated sebocytes of sebaceous glands and undetectable in the IFE or the hair follicles (Fig.
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From page 61...
... Note strong expression of GLI 1 in the nuclei of cells in the normal sebaceous glands (arrowheads in c) and newly differentiating sebocytes along the deformed transgenic hair follicles (arrowheads in d)
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From page 62...
... SHH promotes proliferation of progenitor cells of the hair lineage, whereas IHH stimulates proliferation of sebocyte precursors. The IHH signal is proposed to be produced by differentiated sebocytes and act on the sebocyte progenitors in a paracrine fashion.
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From page 63...
... We are far from understanding the detailed interactions between Wnt and Wh signaling cascades in the epidermis and how they, in turn, interact with the numerous other signaling pathways that control epidermal stem cell fate (1, 2~. The recent find~ng that in transgenic mouse epidermis the same f-catenin mutation exerts different effects depending on the cells in which it is expressed underlines the importance of cellular context and microenvironment in the control of tissue renewal and differentiation (114.
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From page 64...
... 21. Hahn, H., Wicking, C., Zaphiropoulous, P
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Key Terms

  • hair follicle
  • differentiated sebocytes
  • cruz biotechnology
  • santa cruz
  • skin tumors

  • sebaceous glands
  • stimulates proliferation
  • sebocyte progenitors
  • signaling pathway
  • mature sebocytes

  • hair follicles
  • transgenic mice
  • sebocyte differentiation
  • undifferentiated sebocytes
  • research genetics

  • progenitor cells
  • specific immunoreactivity
  • transgenic mouse
  • nile red
  • human sebocytes

  • undifferentiated cells
  • stem cells
  • ihh protein
  • red staining
  • stem cell

  • promotes proliferation
  • sebaceous adenomas
  • normal sebaceous
  • spontaneous skin
  • primary antibodies


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