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Regenerative Medicine (2003) / Chapter Skim
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3 Maintenance of stem cell populations in plants
Pages 7-13

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From page 7...
... Floral meristems have the same general structure and organization as SAMs. Each floral meristem produces a flower consisting of four types of floral organs: sepals, petals, stamens (male reproductive organs)
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From page 8...
... Thus all four genes act in the same genetic pathway to maintain the appropriate amount of stem cell accumulation in shoot and floral meristems. A Short-Range Signaling Pathway Maintains Stem Cell Homeostasis All three CLV genes have been cloned and found to encode components of a meristem signal transduction pathway.
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From page 9...
... CLV3 mRNA ~s not found in peripheral meristem cells, mature stem tissues, or lateral organs. CLV3 is also expressed in the stem cell populations of all axillary shoot meristems and floral meristems.
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From page 10...
... What is the biological basis for signaling through the CLV complex in meristematic cells? Genetic and molecular evidence has led to the conclusion that the CLV signaling pathway is part of a negative feedback loop that controls stem cell fate in the Arab~dopsis shoot apex.
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From page 11...
... Therefore we conclude from this work that CLV3 functions as a secreted protein that activates the CLV stem cell signaling pathway in the extracellular space. A Temporal Feedback Loop Terminates Stem Cell Activity in Flowers Flowers are produced from floral meristems, which are derived from the SAM and likewise harbor a stem cell reservoir that PNAS I September 30, 2003 I vol.
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From page 12...
... Thus the termination of stem cell activity in floral meristems is mediated by a temporal negative feedback loop requiring both flower patterning and stem cell maintenance genes. As in SAMs, WUS promotes maintenance of the stem cell domain in floral meristems to permit the generation of the full complement of floral organs.
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From page 13...
... We and others have demonstrated that stem cell fate in shoot and floral meristems is controlled by a signal transduc tion pathway consisting of the CLV receptor complex and the WUS transcription factor. We have shown that this pathway consists of both plant-specific proteins and those with simi larity to animal proteins, and that activation of the pathway occurs extracellularly.
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Key Terms

  • floral meristems
  • floral meristem
  • stem cells
  • cell activity
  • feedback loop

  • cell population
  • clv signaling
  • cell fate
  • cell maintenance
  • signaling pathway

  • signal transduction
  • apical meristem
  • kinase domain
  • lateral organs
  • shoot apical

  • cell divisions
  • null mutants
  • meristem activity
  • expression domain
  • cell reservoir

  • wus expression
  • extracellular space
  • terminate stem
  • signal peptide
  • clv pathway

  • developing floral
  • cell termination
  • transduction pathway
  • model plant
  • signaling complex


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