Gulf War and Health Updated Literature Review of Sarin (2004) / Chapter Skim
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4 Conclusions
4 Conclusions
Pages 91-102
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From page 91... ...
For each relevant health outcome, epidemiology studies that examined that outcome are reviewed followed by the conclusions for that outcome and the rationale behind that conclusion. NECROLOGIC EFFECTS A number of studies have evaluated the possible relationship between exposure to sarin or cyclosarin and long-lasting neurologic effects.
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From page 92... ...
. The following conclusion was reached m the present report after a review of the literature on sann: There Us sufficient evidence of a causal relationship between exposure to sarin and a dose~dependent acute cholinergic syndrome that Us evident seconds to hours subsequent to sarin exposure and resolves in days to months.
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From page 93... ...
Three years after the Matsumoto attack, fatigue, headache, and the visual disturbances asthenopia, blu red vision, and narrowing of visual field were more common among people who reported signs of the acute cholinergic syndrome than among those who lived near the satin release site who did not have signs of the cholinergic syndrome (Nakajima et al., 1998, 1999)
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From page 94... ...
People's reports that they had exposure to "chemical-wa fare agents" have been associated with necrologic findings in several studies: cogmitive dysfunction, depression, and fibromyalgia aowa Persian Gulf Study Group, 1997) ; majordepression and anxiety (Goss Gilroy inc., 1998)
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From page 95... ...
Studies of Gulf War veterans found PTSD associated with self-reports of potential exposures m the Gulf War (e.g., Goss Gilroy inc., 1998; Proctor et al., 1998)
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From page 96... ...
The wide range of traumatic exposures associated with PTSD prompted Veterans Ad ninisrration researchers to examine, in a large populationbased study of Gulf War veterans, the combined effect of what they defined as three major combat stressors: 1) "hearing chemical alarms or wearing protective gear"; 2)
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From page 97... ...
Those potential exposures related to sarin for which associations have been seen include self-reports of hearing chemical alarms and wearing protective gear. As discussed earlier, those self-reports of potential indicators of exposure do not provide strong evidence of m exposure effect relationship and, therefore, those studies provide little evidence that those effects are mediated by sarin itself in the case of PTSD md related necrologic effects, hypothetically those effects might be toxicologic effects mediated by sarin, but the committee believes that those effects are more likely emotional and physiologic responses to psychologic trauma.
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From page 98... ...
to be more frequent m the exposed than m nonexposed people. Other studies of veterans showed various cardiovascular effects, but only for deployed versus nondeployed veterans, with no analysis for exposure to sarm (McCauley et al., 2002)
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From page 99... ...
:54 59. Goss Gilroy inc.
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From page 100... ...
Effects of satin on the net tous system in gescue team staff members and police offcets 3 yeats afer the Tokyo subway satin attack. Enviranmental HeaLh Perapettives 109(11)
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From page 101... ...
1998c. Chrome neutohehavioml effects of Tokyo subway sntin poisonihg in telahon t2 postmAttmabe stress disorder.
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