Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants Volume 1 (2007) / Chapter Skim
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8 Monoethanolamine
8 Monoethanolamine
Pages 195-208
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From page 195... ...
, 24-h, and 90-day exposure guidance levels for MEA. The subcommittee's recommendations for MEA exposure levels are provided at the conclusion of this chapter along with a discussion of the adequacy of the data for defining those levels and the research needed to fill the remaining data gaps.
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Continuous exposure to high concentrations of MEA for long periods of time has been reported to pro
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Data are lacking for several toxicity end points, including chronic exposure effects, carcinogenicity, and male reproductive effects. Effects in Humans Accidental Exposures No relevant information was identified.
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Repeated Exposures and Subchronic Toxicity Treon et al.
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199 Monoethanolamine Continuous inhalation exposure studies (24 h per day, 7 days per week) were conducted with MEA using dogs, guinea pigs, and rats (Weeks et al.
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. The effects observed in rats exposed at the high and intermediate exposure concentrations were similar to those observed in guinea pigs similarly exposed.
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Immunotoxicity Repeated-insult skin patch tests for allergenicity in human volunteers have shown negative results (Knaak et al.
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. INHALATION EXPOSURE LEVELS FROM THE NRC AND OTHER ORGANIZATIONS Several organizations have established or proposed inhalation exposure limits or guidelines for MEA.
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1-Hour EEGL In recommending exposure guidance levels for MEA, the subcommittee considered several issues. There is a limited amount of information about the effects associated with the inhalation of MEA.
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U.S. Navy Values NRC Recommended Exposure Level Current Proposed Values EEGL 1h 50 6 4 24 h 3 3 4 CEGL 90 days 0.5 0.5 0.5 Abbreviations: CEGL, continuous exposure guidance level; EEGL, emergency exposure guidance level; h, hour; NRC, National Research Council; ppm, parts per million.
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The subcommittee made the conservative assumption that reduced alertness and reduced activity levels were primary effects that could be used for determining exposure guidance levels. To determine the 1-h EEGL for MEA, the 12-ppm continuous exposure in dogs conducted by Weeks et al.
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To determine a 90-day CEGL, the exposure scenario that resulted in the lowest-effect level was chosen for extrapolation. Rats exposed to MEA at 5 ppm via inhalation for 40 days showed pelt discoloration after 12 days of exposure.
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207 Monoethanolamine ACGIH (American Conference of Governmental Industrial Hygienists)
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Pp. 17-25 in Emergency and Continuous Exposure Guidance Levels for Selected Airborne Contaminants, Vol.
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