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Impact of Revised Airborne Exposure Limits on Non-Stockpile Chemical Materiel Program Activities (2005) / Chapter Skim
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3 Old and New Airborne Exposure Limits
Pages 37-42

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From page 37...
... was not specifically documented in the 1988 Federal Register or TABLE 3-1 1988 and 2003 CDC-Recommended AELs in the 1987 CDC meeting transcript "Safe Disposal of Lethal and 2003 Acute Exposure Guidelines (AEGLs) for GA, Chemical Agents." Mioduszewski et al.
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From page 38...
... For VX, the CDC adjusted The EPA has also developed and now manages a mechanism the relative potency factor from 10 to 12 to reflect increased for establishing short-term emergency exposure limits for toxicity compared with GB and applied a modifying factor airborne chemicals. The process functions through the of 3 to account for an incomplete data set, resulting in a total National Advisory Committee to Establish Acute Exposure composite adjustment of 36 for VX.
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From page 39...
... Both change in or a refinement of its understanding of the demonmethods evaluated the quality and weight of evidence of the strated human toxicity of these agents and were not derived data and applied standardized uncertainty factors to estab- from new or additional scientific data on the toxicity of these lish AELs. nerve agents in humans or animals, and that no overt adverse The CDC used a factor of 12 to represent the potency of health effects have been associated with the exposure limits VX compared with that of GB.
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From page 40...
... SOURCE: Cheryl Maggio, Chemical Materials Agency, tional work week using a factor of 3/5, resulting in a lowest Briefing at AEL videoconference, June 2, 2004. observed adverse effect level (LOAEL)
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From page 41...
... . 3 to accommodate additional uncertainties inherent in using The CDC sulfur mustard GPL is a 12-hour TWA that reflects acute exposure data and a small number of subjects, for a the typical sampling times used in the stockpile program.
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From page 42...
... 895) The recommended changes in the AELs do not reflect change IMPACT OF THE REVISED AELS ON WORKER AND in, nor a refined understanding of, demonstrated human PUBLIC SAFETY toxicity of these substances but rather the changes related from updated and minimally modified risk assessment The revised AELs do not reflect any change in agent assumptions.
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Key Terms

  • alarm level
  • exposure limits
  • airborne exposure
  • sulfur mustard
  • nerve agents

  • exposure data
  • red blood
  • acute exposure
  • blood cell
  • revised aels

  • total uncertainty
  • mustard agent
  • level set
  • derived using
  • uncertainty factors

  • monitoring methods
  • vapor exposure
  • immediately dangerous
  • exposure guidelines
  • cancer potency

  • modified risk
  • human exposure
  • chemical materials
  • recommended aels
  • establish acute

  • dose concentrations
  • reference dose
  • overt adverse
  • population limit
  • materials agency


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