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Health Risks from Exposure to Low Levels of Ionizing Radiation BEIR VII Phase 2 (2006) / Chapter Skim
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Appendix A: Basic Biological and Genetic Concepts
Pages 325-328

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From page 325...
... Appendixes
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From page 327...
... A Basic Biological and Genetic Concepts DNA, Genes, and Chromosomes which respond to particular proteins in a tissue-specific man ner by increasing transcription. At the 3 end is the termina The genetic material of living organisms, DNA, is con tion codon (e.g., TAA, TAG, TGA)
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From page 328...
... Molecular analyses have revealed that a wide variety of mutational changes underlie Mendelian diseases: "micro- Genetic Effects of Radiation lesions," such as single base-pair substitutions, deletions, Exposure of cells and organisms to ionizing radiation insertions, or duplications involving one to a few base pairs; causes DNA damage. The cellular processing of radiationand "gross lesions," such as whole-gene or multigene dele induced damage to DNA by enzymes may result in a return tions, complex rearrangements, and large insertions and du to normal sequence and structure (Lobrich and others 1995)
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Key Terms

  • ionizing radi
  • changes induced


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