Computer Assisted Modeling Contributions of Computational Approaches to Elucidating Macromolecular Structure and Function (1987) / Chapter Skim
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2 Introduction
2 Introduction
Pages 18-22
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From page 18... ...
In general, there is a one-to-one correspondence between the amino acid sequence specified by the DNA code and that actually found in the protein. Processing, however, of the DNA itself, the transcribed RNA, or the translated protein frequently obscures this correspondence and makes it mandatory to verify the amino acid sequence directly.
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From page 19... ...
First, it is now apparent that globular proteins of more than 100 to 300 residues are constructed from independent domains, each of which is built according to the Kauzmann hypothesis (Wetiaufer, 1973~. Second, membrane spanning proteins appear to reflect similar thermodynamic principles.
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From page 20... ...
Thus, their geometry is governed to a significant degree by tertiary interactions, rather than by the simple hydrogen bonding that dominates the fibrous proteins ant} nucleic acid helices. This complexity leaves us with what has frequently been called the "protein folding problem": how to calculate the tertiary structure of a protein to a useful degree of accuracy from the amino acid sequence.
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From page 21... ...
Further, the need to make rational plans for modification of protein properties is a major issue for all aspects of the biotechnology industry. A thorough understanding of the growth and development of living organisms depends crucially on a molecular structural and functional description.
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From page 22... ...
In the broadest terms, the convergence of results from experiment and theory yields useful models of protein and nucleic acid structure and function. Given the very large number of sequences expected in the next two decades, we estimate that thousands of these wiD yield useful structural calculations.
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