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Toxicity Testing for Assessment of Environmental Agents Interim Report (2006) / Chapter Skim
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Appendix B: Testing Protocols
Pages 240-244

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From page 240...
... Appendix B Testing Protocols OPPTS HARMONIZED TESTING GUIDELINES1 Series 870 Health Effects 870.1000 Acute toxicity testing-background 870.1100 Acute oral toxicity 870.1200 Acute dermal toxicity 870.1300 Acute inhalation toxicity 870.2400 Acute eye irritation 870.2500 Acute dermal irritation 870.2600 Skin sensitization 870.3050 Repeated dose 28-day oral toxicity study in rodents 870.3100 90-Day oral toxicity in rodents 870.3150 90-Day oral toxicity in nonrodent 870.3200 21/28-Day dermal toxicity 870.3250 90-Day dermal toxicity 870.3465 90-Day inhalation toxicity 870.3550 Reproduction/developmental toxicity screening test 870.3650 Combined repeated dose toxicity study with the reproduction/ developmental toxicity screening test 870.3700 Prenatal developmental toxicity study 1 The EPA OPPTS Harmonized Guidelines can be found online at http://www.epa.gov/opptsfrs/home/guidelin.htm.
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From page 241...
... Appendix B 241 870.3800 Reproduction and fertility effects 870.4100 Chronic toxicity 870.4200 Carcinogenicity 870.4300 Combined chronic toxicity/carcinogenicity 870.5100 Bacterial reverse mutation test 870.5140 Gene mutation in Aspergillus nidulans 870.5195 Mouse biochemical specific locus test 870.5200 Mouse visible specific locus test 870.5250 Gene mutation in Neurospora crassa 870.5275 Sex-linked recessive lethal test in Drosophila melanogaster 870.5300 In vitro mammalian cell gene mutation test 870.5375 In vitro mammalian chromosome aberration test 870.5380 Mammalian spermatogonial chromosomal aberration test 870.5385 Mammalian bone marrow chromosomal aberration test 870.5395 Mammalian erythrocyte micronucleus test 870.5450 Rodent dominant lethal assay 870.5460 Rodent heritable translocation assays 870.5500 Bacterial DNA damage or repair tests 870.5550 Unscheduled DNA synthesis in mammalian cells in culture 870.5575 Mitotic gene conversion in Saccharomyces cerevisiae 870.5900 In vitro sister chromatid exchange assay 870.5915 In vivo sister chromatid exchange assay 870.6100 Acute and 28-day delayed neurotoxicity of organophosphorus substances 870.6200 Neurotoxicity screening battery 870.6300 Developmental neurotoxicity study 870.6500 Schedule-controlled operant behavior 870.6850 Peripheral nerve function 870.6855 Neurophysiology Sensory evoked potentials 870.7200 Companion animal safety 870.7485 Metabolism and pharmacokinetics 870.7600 Dermal penetration 870.7800 Immunotoxicity 870.8355 Combined Chronic Toxicity/Carcinogenicity Testing of Respirable Fibrous Particles
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From page 242...
... 413 Subchronic Inhalation Toxicity: 90-day Study (Original Guideline, adopted 12th May 1981) 414 Prenatal Developmental Toxicity Study (Updated Guideline, adopted 22nd January 2001)
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From page 243...
... 422 Combined Repeated Dose Toxicity Study with the Reproduction/ Developmental Toxicity Screening Test (Original Guideline, adopted 22nd March 1996) 423 Acute Oral toxicity - Acute Toxic Class Method (Updated Guide line, adopted 20th December 2001)
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From page 244...
... 482 Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro (Original Guideline, adopted 23rd October 1986) 483 Mammalian Spermatogonial Chromosome Aberration Test (Original Guideline, adopted 21st July 1997)
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Key Terms

  • updated guideline
  • repeated dose
  • toxicity study
  • oral toxicity
  • aberration test

  • acute oral
  • mutation test
  • screening test
  • toxicity screening
  • vitro mammalian

  • chromosomal aberration
  • gene mutation
  • mammalian bone
  • mammalian cells
  • unscheduled dna

  • marrow chromosomal
  • lethal test
  • delayed neurotoxicity
  • vitro skin
  • reproduction toxicity

  • dna synthesis
  • mammalian cell
  • dose toxicity
  • combined repeated
  • acute dermal

  • bone marrow
  • erythrocyte micronucleus
  • reverse mutation
  • mammalian chromosomal
  • local lymph


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