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Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents Appropriate Use of Animal Models (2006) / Chapter Skim
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1 Introduction
Pages 7-10

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From page 7...
... Developing animal models of human exposure to inhaled infectious agents is a formidable endeavor for a number of reasons, including reproducibility issues that complicate interpretation of intervention studies. Under the direction of a committee, a 1-2 day workshop will be organized to bring together experts in using animal models to test interventions against aerosolized biological terrorism agents with specialists in other areas of biological 7
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From page 8...
... COMMITTEE PROCESS On July 6th ­ 7th, 2005, the Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents convened a workshop at the National Academy of Sciences building in Washington D.C. (see Appendix A for agenda)
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From page 9...
... In addition to the numerous scientific concerns, such as developing appropriate models and ensuring suitable biosecurity and biosafety for work with dangerous pathogens, there are also legal and regulatory issues. Some constraints are imposed by legislation designed to limit access to such pathogens.
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From page 10...
... ." The committee focused on improving and standardizing animal studies that generate efficacy data. Due to scientific and regulatory demands, these studies require consistent and reproducible exposures that result in a disease state that approximates the human disease.
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Key Terms

  • animal model
  • select agents
  • aerosolized bioterrorism
  • animal models
  • appropriate animal

  • animal studies
  • biological agents
  • inhaled select
  • dangerous pathogens
  • nonhuman primates

  • standardizing animal
  • developing vaccines
  • bioterrorism agent
  • otherwise acquire
  • appropriate challenge

  • state party
  • following inhalation
  • developing appropriate
  • scientific concerns
  • human disease

  • offensive purposes
  • select agent
  • toxins whatever
  • appropriate models
  • dose response

  • peaceful purposes
  • toxin weapons
  • excluding plant
  • challenge dose
  • committee focused


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