Skip to main content

Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents Appropriate Use of Animal Models (2006) / Chapter Skim
Currently Skimming:

Summary
Pages 1-6

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 1...
... . Since, during the course of studying bioterrorism agents, it is not ethically appropriate to deliberately expose human subjects to bioterrorism agents, development of countermeasures relies on the ability of the scientific community to adequately test the effectiveness of countermeasures in animal models.
Read the entire page →
From page 2...
... CHARGE TO THE AUTHORING COMMITTEE The NIAID approached the National Research Council with a request that it prepare a short consensus report that articulates the difficulties of testing countermeasures to aerosolized bioterrorism agents in animals and identifies opportunities that can be pursued to improve current testing efforts. As part of this project, NIAID requested that a workshop be organized to bring together select agent researchers, including researchers from NIAID and U.S.
Read the entire page →
From page 3...
... So that future studies to test countermeasures can be compared and reproduced, the Committee recommends that specific parameters be measured and reported as part of a standard operating procedure adopted by researchers studying aerosolized bioterrorism agents. Researchers should measure particle properties including aerodynamic size, size distribution, geometric size and shape, electrical charge, chemical composition, irritancy, and mass concentration (mass of particles per unit mass of air)
Read the entire page →
From page 4...
... In addition, the Committee found a wide variation in published LD50 values in the available literature making the selection of dose difficult. Therefore, the Committee recommends obtaining statistical advice when designing an animal study to develop or test a countermeasure.
Read the entire page →
From page 5...
... In order to address the need for rapid development of countermeasures, while striking an appropriate balance between efficacy and safety, the Committee recommends that the FDA improve the process by which new countermeasures are approved by working with researchers to draft and finalize practical guidelines to ensure that applicants can effectively meet approval requirements.
Read the entire page →

Key Terms

  • bioterrorism agents
  • aerosolized bioterrorism
  • animal model
  • testing countermeasures
  • developing countermeasures

  • appropriate animal
  • human disease
  • infectious agents
  • efficacy data
  • disease process

  • animal efficacy
  • expose human
  • testing interventions
  • producing appropriate
  • aerosol form

  • terrorism agents
  • test countermeasures
  • natural history
  • challenges associated
  • animal study

  • bioterrorism agent
  • studying bioterrorism
  • studying aerosolized
  • committee organized
  • human population

  • widespread disease
  • testing efforts
  • human subjects
  • current testing
  • causes human


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.