Nutrigenomics and Beyond Informing the Future: Workshop Summary (2007) / Chapter Skim
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Appendix A: Glossary
Appendix A: Glossary
Pages 61-64
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From page 61... ...
Appendix A Glossary ABBREVIATIONS/ACRONYMS CVD Cardiovascular disease Dnmt DNA methyltransferase gene FLP Fibrinogen-like proteins FRT FLP recognition target HDAC Histone deacetlyase IAP Intracisternal A-particle ICF Immunedeficiency Centromeric region instability and Facial abnormalities IPE IAP proximal enhancer element MeCP2 Methylene-CpG-binding protein MTHFR Methylene-tetrahydrofolate reductase SHMT Serine hydroxymethyltransferase SNP Single nucleotide polymorphism DEFINITIONS APC tumor suppressor The APC tumor suppressor gene is mutated in familial adenoma tous polyposis and in approximately 80 percent of sporadic colon cancers. Chimera An individual or organism whose cells and tissues have non-uniform or"mosaic" genetic elements.
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From page 62... ...
. A null muta tion is introduced into a gene by designed alteration in a cloned DNA sequence; the sequence is then introduced into the genome by homologous recombination and replacement of the normal allele in embryonic stem cells, which, when injected into mouse embryos, gives rise to chimeric animals that no longer carry a gene they would normally have carried.
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From page 63... ...
Pleiotropy The ability of a single gene to produce multiple phenotypic effects. Ras MAP kinase A signal transduction pathway that mediates the growth-promoting effects of the tyrosine kinase receptor family of hormones.
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