Biosocial Surveys (2008) / Chapter Skim
Currently Skimming:
13 Minimally Invasive and Innovative Methods for Biomeasure Collection in Population-Based Research--Stacy Tessler Lindau and Thomas W. McDade
13 Minimally Invasive and Innovative Methods for Biomeasure Collection in Population-Based Research--Stacy Tessler Lindau and Thomas W. McDade
Pages 251-277
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 251... ...
Hybridization of gold standard social science methodologies with minimally invasive techniques for biophysiological data collection in the home or in vivo defines a new frontier for health research. In large part, these advances derive from rich traditions of field-based research that have valued the integration of multilevel data toward an understanding of human health and development.
|
From page 252... ...
ISSUES IN THE APPLICATION OF MINIMALLY INVASIVE METHODS Biological measures collected in the population setting can include direct measures of physical or physiological characteristics (e.g., hip circumference, blood pressure) , functional testing (e.g., cognitive function, balance, grip strength)
|
From page 253... ...
. Minimally invasive methods aim to minimize burden to and maximize the safety of research subjects and data collectors and to contain research costs (York, Mahay, and Lindau, 2004; Mack, 2001)
|
From page 254... ...
4. Can be self-administered or implemented by single data collector during a single visit.
|
From page 255... ...
Grip strength offers a relatively simple, minimally invasive measure of motor performance that has been shown to correlate with health status and a variety of health outcomes, including general physical function, bone density, mobility, and long-term mortality (Schaubert and Bohannon, 2005; Bohannon, 2001)
|
From page 256... ...
Dried blood spots -- drops of capillary whole blood collected on filter paper following a simple prick of the finger -- represent a viable
|
From page 257... ...
in Large Population-Based Studies Study N Biomarkers in DBS Great Smoky Mountains Study 1,071 Androstenedione, DHEAS, EBV antibodies, estradiol, FSH, LH, testosterone Health and Retirement Study 7,000a CRP, HbA1c, total cholesterol, HDL Los Angeles Family and Neighborhood 5,000a CRP, EBV antibodies, HbA1c, Survey total cholesterol, HDL National Longitudinal Study of 17,000a CRP, EBV antibodies, HbA1c Adolescent Health National Social Life, Health, and Aging 1,945 CRP, EBV antibodies, HbA1c, Project hemoglobin Work and Iron Status Evaluation 18,000 CRP, transferrin receptor Tsimane' Amazonian Panel Study 600b CRP, EBV antibodies, transferrin receptor, leptin aProjected;final plans for analyses are to be determined. bPanel study; 3 waves of dried blood spots.
|
From page 258... ...
. Advantages of dried blood spots include the minimally invasive sample collection procedure, simplified field logistics associated with sample processing, transport, and storage, and long-term stability under freezer storage that allows for future analyses as new biomarkers of interest, such as genetic markers, emerge (McDade et al., 2007)
|
From page 259... ...
of collection and therefore requires cold storage or packaging. This method has been widely used and found acceptable in population studies with younger and older samples, men and women, and in a variety of cultural settings (Auerswald, Sugano, Ellen, and Klausner, 2006; Zheng et al., 2005; Serlin et al., 2002; Wawer et al., 1998)
|
From page 260... ...
. The use of oral stimulants to promote saliva production and the absorption of saliva into cotton rolls to facilitate sample collection have been shown to modify assay results for some, but not all, analytes (Shirtcliff, Granger, Schwartz, and Curran, 2001; Schwartz, Granger, Susman, Gunnar, and Laird, 1998)
|
From page 261... ...
Spirometry Pulmonary function testing is a mainstay of pulmonary medicine and plays an important role in the monitoring of such common diseases as asthma and obstructive pulmonary diseases. Spirometry has been used in several population studies, providing measures of lung volume (e.g., forced expiratory volume in one second or FEV1)
|
From page 262... ...
. Hearing Technological advances have significantly facilitated the transfer of audiometrics from the clinical to the population setting; in the near future, handheld and laptop-based platforms for hearing testing are likely to replace gold standard audiometry equipment even in clinical settings.
|
From page 263... ...
It has been widely used in population studies with acceptable performance compared with audiometry in detecting hearing loss. Older measures used to screen for hearing loss aim to detect threshold sensitivity to whispered voice, the sound of the examiner's fingers rubbing together, or vibratory sensation with a tuning fork.
|
From page 264... ...
Devices vary in weight, ease of setup, whether they can operate on batteries, and the conditions under which cartridges must be stored prior to use. A single finger prick can provide capillary whole blood for onsite analysis, as well as for collection on filter paper as dried blood spots.
|
From page 265... ...
Aside from use by hand surgeons, therapists, and neurologists to quantify neurological deficit and recovery, for example before and after hand surgery, population studies are limited to military personnel or workers using vibratory equipment (Wild et al., 2001) or method validation studies (Kaneko, Asai, and Kanda, 2005)
|
From page 266... ...
. Olfaction Over the last several years, a growing body of evidence linking olfactory function to cognitive decline at older ages has prompted both public and research interest in this area and has motivated development of portable, minimally invasive, efficient olfactory function tests.
|
From page 267... ...
Although used primarily in the clinical research setting, the laptop-based operation and data capture offer unique advantages over other olfactory test methods. The NSHAP study protocol for olfactory function testing in a large probability sample of older adults is an adaptation of the short Sniffin' Sticks olfactory function screening method (Mueller and Renner, 2006)
|
From page 268... ...
In almost all cases, implementation of vaginal sampling in population studies requires a professional results reporting and counseling mechanism, such as that offered by the American Social Health Association. Magnetic Resonance Imaging Magnetic resonance imaging (MRI)
|
From page 269... ...
. Recently, Kahneman and colleagues reported on the Day Reconstruction Method, a hybrid of experience sampling methods and time-budget measurement (Kahneman, Krueger, Schkade, Schwarz, and Stone, 2004)
|
From page 270... ...
In the case of biological specimens, such as blood spots, saliva, vaginal samples, and urine, the power of the method is limited not by cooperation of the research participant, but by the availability and translation of suitable assays. The importance of high-quality, well-trained data collectors who embrace the rationale for biomeasure collection and can convey this to research participants cannot be underestimated.
|
From page 271... ...
. Assessment of gustatory function by means of tasting tablets.
|
From page 272... ...
. Development of the University of Pennsylvania smell identification test: A standardized microencapsulated test of olfactory function.
|
From page 273... ...
. Screening of olfactory function with a four-minute odor identification test: Reliability, normative data, and investigations in patients with olfactory loss.
|
From page 274... ...
. What a drop can do: Dried blood spots as a minimally-invasive method for integrating biomarkers into population-based research.
|
From page 275... ...
. A new procedure for the short screening of olfactory function using five items from the Sniffin Sticks identification test kit.
|
From page 276... ...
. Hazardous events associ ated with impaired olfactory function.
|
From page 277... ...
American Journal of Physi� cal Anthropology, 104(1)
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.