Combined Exposures to Hydrogen Cyanide and Carbon Monoxide in Army Operations Initial Report (2008) / Chapter Skim
Currently Skimming:
2 Mechanisms of Carbon Monoxide and Hydrogen Cyanide Toxicity
2 Mechanisms of Carbon Monoxide and Hydrogen Cyanide Toxicity
Pages 7-8
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 7... ...
Under conditions where CO exposures are rapidly changing, such as occurs in the enclosed environment of the tank cabin during gun firing, spike changes in CO concentration are buffered both by the high lung volume compared to tidal volumes, as well as the slow uptake into pulmonary capillary blood. Under conditions where ambient CO concentrations are changing rapidly, the use of the CFK equation to calculate COHb levels needs to be verified with blood COHb measurements.
|
From page 8... ...
Although HCN is a highly reactive compound and is known to form simple salts with alkali earth cations and ionic complexes of varying strengths with metal cations, the major mechanism of toxicity arises from its reversible binding to an iron containing heme group of cytochrome a3 with resulting inhibition of mitochondrial electron chain transport, decreased energy formation and changes in the cellular redox state producing metabolic acidosis. As with O2, HCN binds to heme Fe2+ in reduced cytochrome a3.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.