The Future of Human Healthspan Demography, Evolution, Medicine, and Bioengineering: Task Group Summaries (2008) / Chapter Skim
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Inflammation's Effects on Aging
Inflammation's Effects on Aging
Pages 93-100
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From page 93... ...
The scope should include human genomics and population diversity, multigenerational effects, and changing ecological factors. As urban populations continue to grow and as water and air quality deteriorate globally, we may anticipate increasing global exposure to infection and inflammation.
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From page 94... ...
More generically, can algorithms be developed to arrive at rational conclusions with regard to risk assessments for individuals and cost-benefit analyses for the case of populationwide interventions? • Pharmaceutical companies are at high risk for costly lawsuits involving unanticipated serious complications of new drugs and vaccines, the development of which requires investments of millions of dollars.
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From page 95... ...
Kuchel, University of Connecticut • Sarah Kummerfeld, Stanford University • J Christopher Love, Massachusetts Institute of Technology • Helen Vlassara, Mount Sinai School of Medicine • Mary White, Centers for Disease Control and Prevention • Allyson Collins, Massachusetts Institute of Technology TASK GROUP SUMMARY By Allyson Collins, Graduate Student, Science Writing, Massachusetts Institute of Technology "Aging begins at fertilization," said Caleb Finch, codirector of the University of Southern California's Alzheimer's Disease Research Center and professor in the neurobiology of aging.
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From page 96... ...
Many interacting aspects contribute, including the endogenous factors such as metabolic and hormonal changes, gender, race, and genetic variation, and the exogenous factors such as diet, physical activity, environmental pollutants or irritants, socioeconomic status, and stress. Therefore, by reducing or eliminating these causes, age-related diseases could also decline, possibly resulting in an increased healthspan and ultimately a longer lifespan.
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From page 97... ...
, harmful compounds produced after consuming heated, sterilized, or processed foods, which may significantly contribute to oxidative stress and chronic diseases. Also, changes in our culture have brought about transformations in patterns of physical activity, socioeconomic status, stress, chronic infections, and the environment, all of which increasingly affect inflammation.
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From page 98... ...
Approaching this issue in terms of gender naturally leads to questioning the effects of hormones on innate immune responses. The group proposed the naked mole rat, which doesn't undergo menopause, as an animal model for studies of hormone effects and gender differences in aging inflammatory responses.
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From page 99... ...
Physicians need low-cost, minimally invasive, rapid methods for analyzing reactive oxygen species and AGEs that could be performed during annual physicals. This type of system could even lead to home-based monitoring of OS markers, similar to diabetic kits for tracking glucose levels.
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From page 100... ...
100 the future of human healTHspan mixed with both basic and clinical research backgrounds. Each member offered a fresh perspective on the topic of inflammation and aging, and each left with a detailed list of questions and a variety of solutions that may not have been conceived without this interdisciplinary experience.
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