Managing Health Effects of Beryllium Exposure (2008) / Chapter Skim
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6 Assessment of Other Health End Points
6 Assessment of Other Health End Points
Pages 123-126
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From page 123... ...
No human studies that could be used to derive an oral RfD were identified by EPA. This chapter examines the literature relevant to determining whether inhaled beryllium has systemic health effects other than CBD and cancer that might be critical end points for use in deriving health-based standards.
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From page 124... ...
EPA's (1998b) review focused on hazard assessment of environmentally relevant doses and concluded that "the potential of beryllium to induce developmental and/or reproductive effects has not been adequately assessed" (p.
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From page 125... ...
OTHER EFFECTS Extrapulmonary effects of beryllium compounds are not common and are most often secondary to severe lung disease or related to extrapulmonary granulomatous lesions in humans. Systemic effects of beryllium in animals are gener
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From page 126... ...
SUMMARY Studies of the extrapulmonary effects of different forms of beryllium have not comprehensively evaluated doses relevant to current occupational exposures, but there is little indication that such studies would yield useful information. Studies of reproductive and development effects and studies of other extrapulmonary effects have generally been conducted only at doses higher than the lowest doses that induce CBD or cancer.
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