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7 Moving Forward
Pages 22-24

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From page 22...
... (The committee recognizes that alternative approaches may provide additional insights into the conjoined effects of exposure to two or more substances. However, until further findings suggest otherwise, we are confident that the hazard quotient approach provides an appropriate method for establishing exposure limits for combined exposures.)
From page 23...
... Factors That May Modify Effects of Carbon Monoxide Because of the weakness of the database regarding adverse effects of small increases in body CO on brain functions, such as those involved in decision making and alertness, it is not possible at this time to make conclusions about the extent to which environmental factors, such as temperature and humidity, can confound relationships between CO exposures and performance. However, environmental factors can alter CO uptake that can potentially translate into adverse effects of CO.
From page 24...
... The TGAS models would probably need to be restructured and calibrated to estimate the combustion-product-exposure conditions presented to the committee and also to estimate internal dosimetrics, such as COHb resulting from CO exposure.


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