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Combined Exposures to Hydrogen Cyanide and Carbon Monoxide in Army Operations Final Report (2008) / Chapter Skim
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Appendix B: Previous Applications of the Coburn-Forster-Kane Equation to Predict Carboxyhemoglobin Levels Resulting from Varying Carbon Monoxide Exposures
Pages 32-34

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From page 32...
... The authors concluded that the CFK equation provided the best fit to the experimental COHb data. In this study, Peterson and Stewart also included an intermittent or discontinuous exposure regimen of 3 h and 1 h of CO exposure separated by a 2-h non-exposure period, and another exposure regimen in which CO concentration gradually increased from ambient level to 1,000 ppm in a 2-h period and was held at this level for another hour.
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From page 33...
... To test the goodness of fit of the CFK equation to predict COHb for other exposure scenarios, Peterson and Stewart extrapolated from these experimental data with CO concentrations of 8.7, 25, 35, 50, 200, 500, and 1,000 ppm and concluded that the CFK equation fit the resulting data very well. From these observations and the results of their previous studies investigating discontinuous or intermittent CO exposures, Peterson and Stewart concluded, "Even though the CFK equation has not been completely tested at all levels of all parameters (and such testing is, in fact, impossible)
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From page 34...
... 1987a. Percent carboxyhemoglobin in resting humans exposed repeatedly to 1,500 and 7,500 ppm CO.
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Key Terms

  • alveolar ventilation
  • cohb data
  • carbon monoxide
  • values predicted
  • test subjects

  • cohb values
  • various exposure
  • predicting cohb
  • experimental cohb
  • predicted using

  • exposure regimen
  • ventilation rate
  • pulsatile spikes
  • stewart concluded
  • army personnel

  • sedentary subjects
  • levels resulting
  • values compared
  • training sessions
  • distinctive pattern

  • dciem values
  • equation provided
  • exposure regimens
  • exercising humans
  • assessing army

  • solid scientific
  • predicts cohb
  • exposure durations
  • range reported
  • carboxyhemoglobin levels


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