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Combined Exposures to Hydrogen Cyanide and Carbon Monoxide in Army Operations Final Report (2008) / Chapter Skim
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Appendix C: Proposed Experiments to Study Effects of Rapid Changes in Inspired Carbon Monoxide Concentrations and Effects of Rapid Changes in Pulmonary Ventilation
Pages 35-36

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From page 35...
... These data will allow determination if rapid increases in CO concentrations during spikes are taken up via the lungs, and effects of slower interspike CO increases on CO uptake. It is anticipated that an equation can be developed that can be used in determining errors inherent in the use of the CFK equation by converting rapid changes in inspired CO concentrations into an "average" or buffered alveolar gas CO concentration that drives pulmonary CO uptake.
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From page 36...
... EXPERIMENT 3: EFFECTS OF SIMULTANEOUS INCREASES IN INSPIRED CO CONCENTRATION AND VENTILATION ON CO UPTAKE, VENOUS BLOOD COHb, AND COHb PREDICTED BY THE CFK EQUATION The goal of these experiments is to duplicate experiments described in Experiments 1 and 2 but under conditions of simultaneous rapid changes in ventilation and inspired CO. After control data are obtained, the subjects will start exercising, and inspired CO will be increased.
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Key Terms

  • cfk equation
  • rapid changes
  • venous blood
  • expired gas
  • mixed expired

  • allow determination
  • measured venous
  • body stores
  • minute ventilation
  • cohb levels

  • values calculated
  • calculated using
  • rapidly change
  • contours duplicate
  • converting rapid

  • approaches obtained
  • comparing values
  • determining errors
  • firing sequences
  • uptake subjects

  • measured blood
  • stant value
  • relevant inspired
  • directly measured
  • cohb obtained

  • monitored using
  • experiment requires
  • requires technology
  • single firing
  • kept constant


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