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Aging in Today's Environment (1987) / Chapter Skim
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1 Aging and Environmental Exposure
Pages 10-14

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From page 10...
... If mechanisms of development of disease depend more on basic underlying processes of aging than on factors that can be eliminated from such processes, the piecemeal study of the diseases of old age will have only limited success. Our inability to separate the aging processes from environmental influences lies at the heart of the problem.
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From page 11...
... Homeostatic responses are also blunted after an increase in blood glucose concentration, blood pressure, or heart rate. Young adults are protected from environmental stresses by their homeostatic reserves.
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From page 12...
... Even in the labm ratory, environmental influences can be only minimized, not eliminated. The effects of diet and other essential components of the laboratory environment can be successfully reproduced and oh~served as changes in structure, function, and disease states in inbred laboratory animals.
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From page 13...
... But the separation is extremely difficult to discern in experiments relevant to human beings, who age for extended periods in environments that contain multiple agents at various concentrations. The difficulty of applying the results of experiments on aging in laboratory animals to human beings is also related to extrapolation across wide dose ranges, from laboratory to real environment, and from laboratory animal to human being.
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From page 14...
... ) examines potable ~tuatlons far averse environment impacts on the elderly (Chapter 0~$ outUne~ boa the use of model system can expand the knowledge bee in both toxicology ad gerontology (abater 7~, and presents the committee conclusions and reco~end~t~ns (Chapters 8 ad g)
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Key Terms

  • environmental exposure
  • environmental agents
  • heart rate
  • toxic environment
  • laboratory animals

  • laboratory animal
  • environmental exposures
  • life expectancy
  • essential components
  • particularly vulnerable

  • affect aging
  • influences lies
  • multiagent toxic
  • wide dose
  • validity depends

  • absolutely nonperturbing
  • extended periods
  • successfully reproduced
  • constitutive biologic
  • dose ranges

  • tee report
  • piecemeal study
  • examines potable
  • biologic assumptions
  • basic underlying

  • impaired function
  • demographic studies
  • agents acting
  • conduction velocity
  • identify relationships


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