Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (2011) / Chapter Skim
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1 Introduction
1 Introduction
Pages 16-23
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From page 16... ...
In recent years, people who were displaced by Hurricane Katrina and Hurricane Rita and lived in trailers provided by the Federal Emergency Management Agency have reported adverse health effects attributed to formaldehyde exposure. Published research has also indicated a possible link between leukemia and formaldehyde exposure.
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From page 17... ...
Figure 1-2 provides ranges of formaldehyde air concentrations in various environments. Given the pervasive exposure of the general population to some concentration of formaldehyde, federal agencies tasked with protecting public health are concerned about the health effects of formaldehyde exposure.
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From page 18... ...
Given the complex nature of assessing the health effects of formaldehyde and the knowledge that the IRIS assessment will be used as a basis of new regulations, EPA asked NRC to convene a committee to review its draft IRIS assessment.
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0 0 8 09 01 99 91 99 00 4 20 r y 2 r 1 y 19 1 r2 Ju ly u a 10 mbe a u ar y be Jan ne 2 0 e to Se p t M Jan Oc J u Oral RfD Cancer Reassessment of Development of Draft IRIS posted assessment noncancer and draft IRIS assessment on line posted on line cancer risks assessment begun undergoes begun by IRIS agency program review Draft IRIS assessment undergoes interagency review Draft IRIS assessment provided to NRC and released to public FIGURE 1-3 Timeline of the development of the draft IRIS assessment. Abbreviations: IRIS, Integrated Risk Information System; NRC, National Research Council; RfD, and reference dose.
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From page 20... ...
. The committee was asked to review EPA's draft IRIS assessment and to answer questions concerning the identification of potential noncancer health effects, the selection of the points of departure for those health effects, and the basis of the determination of uncertainty factors used to derive the RfCs.
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From page 21... ...
Review and comment on the scientific support for the choices made in developing the preferred quantitative estimates that are based on dose response relationships between several cancers and cumulative inhalation exposure, and consider such issues as the appropriate dose metric given the study design, the alternative metrics, and the suitability of alternative metrics for use in evaluating environmental and residential inhalation exposures to formaldehyde. Review and comment on the scientific rationale for the choices made to develop the supportive estimates that are based on dose-response rela tionships from animal studies of nasal tumors, and consider the analysis of the sensitivity of low-dose estimates from biologically based dose-response models of formaldehyde for upper respiratory tract cancer to small changes in model design or model inputs.
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From page 22... ...
The committee notes that it does not provide a comprehensive discussion of any particular topic or health outcome, although it does provide brief descriptions where necessary to give the reader some context as to what it is recommending. Furthermore, the committee discussed the various health outcomes using the categories presented in the draft IRIS assessment.
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From page 23... ...
U.S. Department of Health and Human Services, Public Health Services, Agency for Toxic Substances and Disease Registry, Atlanta, GA.
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