A Review of the Manufacturing-Related Programs at the National Institute of Standards and Technology Fiscal Year 2012 (2012) / Chapter Skim
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2 Nanomanufacturing
2 Nanomanufacturing
Pages 8-16
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From page 8... ...
These comments are followed by discussions of the Nanomanufacturing activities in terms of their technical merit and scientific caliber, the efficacy of NIST's engagement with outside stakeholders, and program coordination and cohesion across NIST. The same aspects of the Biomanufacturing program are then discussed.
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From page 9... ...
For example, there did not seem to be a consensus in the area as to which of the following descriptions best fits the objectives of the activities in the Nanomanufacturing area: Making small features on large objects, Making nanosized objects, Making nanoscale objects to obtain special properties, Incorporating nanoscale objects in larger objects, and Using nanotechnology to manufacture other things. In his overview presentation, the Director of the Center for Nanoscale Science and Technology (CNST)
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From page 10... ...
(In the PV area, because the industry is heavily driven by end-product pricing -- unlike, just to give one example, precision machine tools -- resulting from intense cost pressures from offshore competition, the need for smart manufacturing in the United States has become especially critical.) Since the PVMC and the BAPVC are specifically funded for PV manufacturing, and since they are just getting started, NIST (which leverages much other electrooptical activity in addition to its PV nanomanufacturing focus)
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From page 11... ...
The semiconductor industry is the largest nanotechnology industry in the United States, and NIST has strongly contributed to a technology roadmap addressing key issues using advances in measurement. Issues addressed at NIST include mobility degradation, the role of series resistance, and lowvoltage reliability.
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From page 12... ...
The NIST work in this area is addressing key issues using advances in measurement, many of which have been incorporated into various standard semiconductor measurement techniques. In addition, NIST has leadership roles in the International Technology Roadmap for Semiconductors.
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From page 13... ...
The program will focus initially on the development of new or improved measurement science, standards, and reference data for more accurately and precisely determining the structures of biologic drugs. Since protein biologics and monoclonal antibodies are emerging as major economic drivers of new drug development and as new therapeutics for unmet medical needs, this focus is ideally suited to leveraging current internal protein science and cell biology programs at NIST.
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From page 14... ...
Thus, NIST believes that developing new methods for understanding and quantifying these complex drug factories will enable the development of new strategies for engineering and controlling CHO cells so as to ensure efficient production and consistent quality of manufactured protein therapeutics. It remains to be seen what these new methods will be and how effectively they will compete against the vast array of molecular biological techniques already employed to reengineer cells and regulate their production profiles.
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From page 15... ...
As stated above, work on protein stability in collaboration with a major pharmaceutical company has taken advantage of the NIST NCNR to develop new tests for the efficacy of proteins stabilized by various glycerol formulations. Also as noted above, in the area of protein structure, NIST has excellent resources available internally and through its 20-plus-year relationship with the University of Maryland's IBBR.
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From page 16... ...
5. In the large CMOS device market, which is dominated by companies with vast resources, NIST should make careful judgments about where it positions itself with respect to device metrology supporting continuation of semiconductor technology advances.
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