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A Guide to Transportation's Role in Public Health Disasters (2006) / Chapter Skim
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Appendix B - Biological Threat Information
Pages 83-86

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From page 83...
... B-1 APPENDIX B Biological Threat Information
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From page 84...
... 7-17 days (average 12) 4 weeks High to moderate Very stable Vaccine protects against large doses in primates Venezuelan Equine Encephalitis Low 10-100 organisms 2-6 days Days to weeks Low Relatively unstable TC 83 protects against 30500 LD50 in hamsters Viral Hemorrhagic Fevers Moderate 1-10 organisms 4-21 days Death between 7-16 days High for Zaire strain, moderate with Sudan Relatively unstable - depends on agent No vaccine Botulism No 0.001 μg/kg is LD50 for type A 1-5 days Death in 24-72 hours; lasts months if not lethal High without respiratory support For weeks in nonmoving water and food 3 dose efficacy 100% against 25-250 LD50 in primates Staph Enterotoxin B No 0.03 μg/person incapacitation 3-12 hours after inhalation Hours < 1% Resistant to freezing No vaccine Ricin No 3-5 μ g/kg is LD50 in mice 18-24 hours Days - death within 10-12 days for ingestion High Stable No vaccine T-2 Mycotoxins No Moderate 2-4 hours Days to months Moderate For years at room temperature No vaccine Note: Table source is the Medical Management of Biological Casualties Handbook, from the United States Army Research Institute for Infectious Diseases.
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From page 85...
... Currently testing vaccine to determine the necessity of skin testing prior to use. IND 610 - inactivated whole cell vaccine given as single 0.5 ml s.c.
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From page 86...
... : 0.5 ml deep SC @ 0, 2 & 12 wk, then yearly boosters CDC trivalent equine antitoxin for serotypes A, B, E (licensed) NA Staphylococcus Enterotoxin B No vaccine available Ventilatory support for inhalation exposure NA Ricin No vaccine available Inhalation: supportive therapy G-I : gastric lavage,super activated charcoal, cathartics NA T-2 Mycotoxins No vaccine available Decontamination of clothing and skin TABLE B-2 (continued)
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Key Terms

  • days death
  • equine antitoxin
  • dose efficacy
  • assumed low
  • relatively unstable

  • available ventilatory
  • boosters cdc
  • ventilatory support
  • yearly boosters
  • vaccine botulism

  • trivalent equine
  • low assumed
  • pentavalent toxoid
  • dod pentavalent
  • available decontamination

  • usually fatal
  • vaccine protects
  • lasts months
  • cdc trivalent
  • spores remain

  • heptaval entequine
  • entequine despeciated
  • days days
  • low relatively
  • stable vaccine

  • weeks low
  • glanders low
  • skin test
  • studies ongoing
  • supportive therapy


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