Monitoring Human Tissues for Toxic Substances (1991) / Chapter Skim
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C: Summary of Workshop
C: Summary of Workshop
Pages 187-200
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From page 187... ...
Others were asked to address specific technical areas that are directly applicable to the NHATS program, including tissue collection, storage and archiving, data management, etc. In addition, several presentations were made about alternative types of monitoring programs 187
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From page 188... ...
General Themes · Human tissue monitoring is valuable and necessary and should be expanded. · Specimen banking should be an integral part of monitoring programs.
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From page 189... ...
The NHMP comprises the National Human Adipose Tissue Survey (NHATS) , which has collected approximately 20,000 specimens since 1967; the National Blood Network (NBN)
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From page 190... ...
Dr. Goldman stressed the importance of having data on background levels of contaminants in human tissues and suggested that these data are generally lacking for most xenobiotics other than lead and heavy metals.
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From page 191... ...
A priority toxicant reference range study is being conducted at CDC and coupled to NHANES III (National Health and Nutrition Examination Survey) in collaboration with ATSDR and the National Center for Health Statistics (NCHS)
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From page 192... ...
The agency has developed ten program areas to aid in the implementation of congressional mandates. Three of the program areas involve evaluation of adverse human health effects and diminished quality of life resulting from exposure to hazardous substances in the environment: health assessments and health studies, toxicological profiles, and exposure and disease registries.
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From page 193... ...
Dr. Shank gave a brief overview of FDA's monitoring programs, including programs that monitor for pesticide residues and toxic elements, including heavy metals, and industrial contaminants.
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Dr. Stevenson stated his bias as strongly in favor of exposure assessment playing a key role in identifying situations which require risk evaluation and in determining public health priorities.
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From page 195... ...
He also stressed the importance of sterility and freshness of the collected tissue: NCI provides iced, sterile containers for their collectors and instructs them on correct collection and storage procedures. Quality control is very important, and samples are packaged appropriately and shipped in insulated containers in wet or dry ice by overnight delivery service.
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From page 196... ...
or in liquid nitrogen vapor, although animal viruses are stored at -70°. Each freezer unit (including alarm system)
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From page 197... ...
Dr. Gannon urged EPA and the Committee on National Monitoring of Human Tissues to consider the Canadian Wildlife Service Great lakes specimen banking program as a model.
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From page 198... ...
FDA has carried out a large-scale monitoring program for pesticide residues since the early 1960s. The program has two principal approaches: commodity monitoring to measure residue levels in domestic and imported food to enforce tolerances and other regulatory limits, and the total diet study to measure intakes of pesticides in foods prepared for consumption.
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From page 199... ...
NIST's approach was to gain experience in the various aspects of specimen banking, including collection, storage and analysis. Although the program was initially intended to focus on four areas human, marine, food and air—funding constraints have limited the focus to human tissues with limited work on the marine sample (e.g., in cooperation with NOAA)
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