Report of the Committee on Mapping and Sequencing the Human Genome (1988) / Chapter Skim
Currently Skimming:
IMPLICATIONS FOR MEDICINE AND SCIENCE
IMPLICATIONS FOR MEDICINE AND SCIENCE
Pages 28-33
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 28... ...
These are but a small subset of the numerous Mendelian disorders for which direct genetic analysis offers the best hope of identifying the responsible genes. The availability of various types of maps of the human genome would greatly facilitate the search for genes related to specific inherited diseases.
|
From page 29... ...
Similarly, the study of individual mutant genes encoding uncharacterized products is certain to illuminate new biochemical and cellular mechanisms related to both normal human physiology and to the development of disease. The rapid identification of disease genes will enable investigators to examine in detail the protein product of such genes and their role in cellular biology.
|
From page 30... ...
Other oncogenes encode proteins that are involved in the response of cells to growth stimulators. As a result of these findings, primary questions regarding cell growth and human cancer have come into sharp focus: What normal human proteins are involved in cell growth and how do they act?
|
From page 31... ...
Many New Human Genes and Proteins Will Be Identified Only a small percentage of the human genes involved in normal development and disease have been identified to date. Mapping and sequencing the human genome will result in the identification of a large number of new genes and their encoded proteins.
|
From page 32... ...
Thus, the orderly development of the human embryo requires that specific gene sets be activated at exactly the right place and time as new cell types arise from multi-potential stem cells. This process is controlled at least in part by regulatory DNA sequences located near the genes.
|
From page 33... ...
In summary, the acquisition of the map and sequence of the human genome will expand our understanding of many basic questions in biology. To maximize this impact, it will be necessary to pursue the analysis of genomes of organisms that can be experimentally manipulated.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.