Report of the Committee on Mapping and Sequencing the Human Genome (1988) / Chapter Skim
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IMPLEMENTATION AND MANAGEMENT STRATEGIES
IMPLEMENTATION AND MANAGEMENT STRATEGIES
Pages 80-90
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From page 80... ...
FUNDING A HUMAN GENOME PROJECT Projects with the Potential to Make Substantial Technological Improvements in Genome Analysis Should Receive Top Priority Mapping and sequencing the human genome poses a severe technological challenge to our present abilities. A complete restriction map has recently been produced for the genome of the bacterium Escherichia coli.
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From page 81... ...
The methods will probably evolve very rapidly, and the strongest and most efficient mapping efforts will provide their first critical tests. For these reasons, a substantial portion of the human genome mapping effort should probably be organized into medium-sized research centers, each with ongoing activities in both development of techniques and actual mapping and each with a reasonable fraction of the various technologies in place or under development.
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From page 82... ...
The central facilities that collect and distribute information and materials should also be supported by contract. Such efforts should also be subject to continuing peer review, both for technical competence and to ensure continuing coordination with the overall effort to map and sequence the human genome.
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From page 83... ...
The committee recommends that the same body also ensure a uniform standard of peer review. The Human Genome Project Requires New and Distinctive Funding of About $200 Million per Year To create the multidisciplinary centers suggested, new laboratories will need to be built, equipped, and staffed.
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From page 84... ...
The Sequencing Effort Should Evolve and Grow with Time Most of the human genome will probably become available in the ordered DNA clone collection as a result of the combined efforts of several multidisciplinary centers. If the envisioned support is forthcoming, the ordered DNA clone collection could be completed within 10 years.
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From page 85... ...
Some portion of research on the human genome is bound to be done outside the United States, mainly in Europe and Japan. One project already started in Japan is supported by major industrial companies, which intend to automate DNA sequencing at the rate of 1 million nucleotides per day.
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From page 86... ...
Organizational Plan A: A Lead Agency and a Scientific Advisory Board The Human Genome Project Should Be Assigned to a Malor Federal Agency. In this plan the human genome project would be sited within a federal agency as an independently funded endeavor.
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From page 87... ...
The NSF has been involved in the development of technology and instrumentation relevant to the human genome project, in the general support of basic biological research, and has a well-established peer review system. Locating the project within one agency does not mean that all the funding for the project would flow from it or that scientists associated with another agency would not be able to obtain funding.
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From page 88... ...
Three government agencies can potentially play leading roles in the human genome project: The National Institutes of Health (NIH) because of their central responsibility for human biomedical research and their exemplary peer-reviewed extramural grant programs; the Department of Energy (DOE)
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From page 89... ...
involved in the project. This IAC would be responsible for overall administration of the project, including funding of research programs and supporting services; administration of a common peer review process, the stock center, and the data center; and the appointment of and response to a Scientific Advisory Board (SAB)
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From page 90... ...
After the assignment of a priority number to each grant and contract, the Interagency Committee would select the applications to be funded. The Scientific Advisory Board in this organizational plan will have similar responsibilities to those outlined in plan A, but will advise both the Interagency Committee and the administrative agency.
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