Committee on Problems of Alcohol A Report of Its Activities From 1949 to 1955, the Research Work It Has Supported and the Place of This Work in the Field of Alcoholism (1956) / Chapter Skim
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II. THE METABOLISM OF ALCOHOL
II. THE METABOLISM OF ALCOHOL
Pages 5-7
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From page 5... ...
regardless of the concentration of alcohol in the blood. Almost all other substances metabolized by the body are metabolized much faster at high concentrations than at low ones, This implies that there may be in the body only a limited amount of the enzyme or enzymes which change alcohol to acetaldehyde; this small amount could act as a limiting factor, keeping the rate of alcohol metabolism down at its observed constant level.
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From page 6... ...
in amounts just proper to account for the limited rate of alcohol metabolism described above. To allow this reaction to occur, diphosphopyridine nucleotide, a molecule containing the vitamin nicotinic acid, must be present; but for unknown reasons, the effects of nicotinic acid deficiency on alcohol metabolism have not yet been specifically investigated.
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From page 7... ...
Since in actuality living muscle barely• metabolizes acetaldehyde at all, it seems unlikely that these enzymes play any important role in the metabolism of acetaldehyde by the living animal. The three others are all present in the liver, which is the primary site of acetaldehyde metabolism, and are called, respectively, xanthine oxidase, aldehyde pxidase and aldehyde dehydrogenase (or mutase)
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