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Appendix E: Evaluation of the Hazard of 0.5 Percent Lead Paint
Pages 45-48

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From page 45... ... We will use two methods for estimating the hazard of paint containing 0.5 percent lead: Method A - The first method of estimating the safety of 0.5 percent lead paint will be made by relating estimated paint intake to fecal lead outputs found in children with blood lead levels (Pb-B) Read the entire page →
From page 46... ... per week could produce fecal lead outputs equal to those found in children with >60 yg Pb-B. Clinical studies in children have indicated that blood lead levels >60 yg Pb/dl are associated with increased risk of later CNS effects.3'23'24'57'73 In contrast, Alexander's balance studies in eleven healthy children receiving a normal diet showed a mean lead intake of 10.61 yg Pb/kg body weight/day and a mean fecal lead output of 5.13 yg/kg/day.4 Using the 46 Read the entire page →
From page 47... ... Since the best available clinical evidence indicates that children with pica can and do ingest 1-3 grams of paint per week and, since the ingestion of between 1 and 2 grams of 0.5 percent lead paint per week would be sufficient to produce daily fecal lead outputs equivalent to those found in children with >60 yg Pb-B, a level of 0.5 percent lead in paint cannot be considered a "safe level." Method B - An alternate method for determining the safety of 0.5 percent lead paint is based on the absorption studies carried out by Kehoe on adult volunteers.^ Kehoe found that blood lead levels increased 17 yg/dl over a period of nine months for each additional mg of lead administered per day. Lead acetate or lead chloride were administered with the diet at dosages of 0.3, 1.0, 2.0 and 3.0 mg Pb/day. Read the entire page →
From page 48... ... The ingestion of 16.82 mg paint/day or 33.64 mg paint per day containing 0.5% lead would result in raising blood lead levels by 17 ug/dl or 34 yg/dl, respectively, in a 10 kg child. Similarly, a 12.5 kg child would need to ingest either 21.02 mg paint/day or 42.06 mg paint per day. Read the entire page →

From page 45...

... We will use two methods for estimating the hazard of paint containing 0.5 percent lead: Method A - The first method of estimating the safety of 0.5 percent lead paint will be made by relating estimated paint intake to fecal lead outputs found in children with blood lead levels (Pb-B)

Read the entire page →

From page 46...

... per week could produce fecal lead outputs equal to those found in children with >60 yg Pb-B. Clinical studies in children have indicated that blood lead levels >60 yg Pb/dl are associated with increased risk of later CNS effects.3'23'24'57'73 In contrast, Alexander's balance studies in eleven healthy children receiving a normal diet showed a mean lead intake of 10.61 yg Pb/kg body weight/day and a mean fecal lead output of 5.13 yg/kg/day.4 Using the 46

Read the entire page →

From page 47...

... Since the best available clinical evidence indicates that children with pica can and do ingest 1-3 grams of paint per week and, since the ingestion of between 1 and 2 grams of 0.5 percent lead paint per week would be sufficient to produce daily fecal lead outputs equivalent to those found in children with >60 yg Pb-B, a level of 0.5 percent lead in paint cannot be considered a "safe level." Method B - An alternate method for determining the safety of 0.5 percent lead paint is based on the absorption studies carried out by Kehoe on adult volunteers.^ Kehoe found that blood lead levels increased 17 yg/dl over a period of nine months for each additional mg of lead administered per day. Lead acetate or lead chloride were administered with the diet at dosages of 0.3, 1.0, 2.0 and 3.0 mg Pb/day.

Read the entire page →

From page 48...

... The ingestion of 16.82 mg paint/day or 33.64 mg paint per day containing 0.5% lead would result in raising blood lead levels by 17 ug/dl or 34 yg/dl, respectively, in a 10 kg child. Similarly, a 12.5 kg child would need to ingest either 21.02 mg paint/day or 42.06 mg paint per day.

Read the entire page →

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Appendix E: Evaluation of the Hazard of 0.5 Percent Lead Paint Pages 45-48

Appendix E: Evaluation of the Hazard of 0.5 Percent Lead Paint
Pages 45-48