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Frontiers of Engineering Reports on Leading-Edge Engineering from the 2014 Symposium (2015) / Chapter Skim
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Biomaterials for Treating Myocardial Infarctions--Jason A. Burdick and Shauna M. Dorsey
Pages 71-78

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
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From page 71...
... Various materials, cells, and therapeutic molecules have demonstrated positive outcomes in the repair of cardiac tissue after infarction and provide insight for future material development and optimization. Further development of injectable hydrogels for cardiac repair will have considerable clinical impact by improving therapies to prevent progression to heart failure.
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From page 72...
... Several focus on treatment after significant tissue remodeling; for example, with tissue engineering, replacement cardiac tissue is developed in the laboratory and then implanted to replace damaged tissue. Another promising approach involves treating the tissue during the acute phase to try to attenuate the remodeling response before significant damage.
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From page 73...
... . Infarcts naturally stiffen over time as wound healing progresses and collagen is deposited; modifying the tissue properties of the infarct region before the body compensates for the remodeling process can limit infarct expansion and post-MI remodeling (Tous et al.
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From page 74...
... . For cardiac applications where the goal is to replace or repair the damaged ECM, natural biomaterials more closely mimic features of the native ECM and can also be therapeutic in their degradation products through the recruitment of cells (Sui et al.
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From page 75...
... . Delivery of therapeutic molecules alone, by either direct myocardial injection or systemic intravenous circulation, has helped restore cardiac function in some animal models, but the short half-life of the molecules and off-target complications limit clinical application (Urbanek et al.
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From page 76...
... . For cardiac applications, injectable hydrogels are useful to deliver antiapoptotic molecules (which limit cell death after injury)
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From page 77...
... 2012. Combining adult stem cells and polymeric devices for tissue engineering in infarcted myocardium.
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From page 78...
... 2005. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long term survival.
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Key Terms

  • injectable hydrogels
  • cardiac repair
  • stem cells
  • heart failure
  • cardiac tissue

  • cell delivery
  • therapeutic molecules
  • cell death
  • tissue engineering
  • infarct expansion

  • synthetic materials
  • bulking agents
  • cell retention
  • limit infarct
  • injectable biomaterials

  • left ventricular
  • infarct region
  • hyaluronic acid
  • cardiac stem
  • cardiac applications

  • cardiac function
  • heart disease
  • cell types
  • tissue repair
  • american heart

  • heart association
  • clinical trials
  • translational research
  • finite element
  • inherent biological


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