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Key Concepts: Chemical Sensitization
Pages 13-34

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From page 13... ... Ideation of the andgen/aDergen in an individual previously sensitized leads to an Serge reaction, such as rbinitis or conjunctivitis. If the son is se~dzed, as in allergic contact dermatitis, then contact will cause an oedematous response and/or a rash. Read the entire page →
From page 14... ... . Sensitization can occur in the lower respiratory tract, usually called hyperse~tivi~ pneumonias (or extrinsic allergic alveoEtis) Read the entire page →
From page 15... ... . The increase of airway or son permeability, permitting processes that lead to mast cell or basophil degranulation, Icads to mediator release. Read the entire page →
From page 16... ... IgG, which has sum high ;~ffinit~r for binding protege may play a role in this function. In rhinids, and probably In asthma, there are specific chemical sensitive mast cells in the epitl~elium, such as formaldehyde-sensitive mast cells In the nasal epithelium, whicl1 are related to increased numbers of mast cell progenitors ~ airway mucosa (Otsuka et al., 1985, 1986, 1987; Beet and Metcalfe 1987~. Read the entire page →
From page 17... ... Irritants can also produce endothelial cell damage which results in arac~donic add metabolism (and circulation of prostaglan- dins, leukotrienes3. Increased permeability leads to ensure of mast cells or basophils, which can then be activated to release other mediators (Thurmond and Dean, 19~. Read the entire page →
From page 18... ... The ~pseudoalle~ or Reactive airway disease syndrome. usually requires exposure to relatively large amounts of the agent, usually occurs without a latency, period after exposure (i.e., no Desensitizations penod) Read the entire page →
From page 19... ... Increased mucoi~tic (decreased ciliary) activity has been shown related to formaldehyde exposure in animals In various studies (Carson et al., 1966; Cralley, 1942; Dalhamn, 1956; Ho~nann and Wynder, 1977; Kensler and Battista, 1963; Kotin, 1966~. Read the entire page →
From page 20... ... ~= - -a O ~ Boom (19~ Ed Dowel et d., (lady) ~ ~ Few Sequent ~ auto Ed ~~ ~ ~ Fad paw. Read the entire page →
From page 21... ... was developed for formaldehyde and was posture for exposed dialysis patients (Rocker et al., 1989~; others have evidently used formaldehyde oonjugated to human serum albumen for immunogiob~ n determinations (see below) Read the entire page →
From page 22... ... 'mian~, 19893 have shown that formaldehyde (like S02 and nickel salts3 increase macrophage phagocytosis and increase hydrogen peroxide levels. The latter promotes lipid metabolism, increases inflammation, and decreases host resistance; these studies have shown little direct effect of HCHO on B cells/imm=m globulins. Read the entire page →
From page 23... ... (1982) reported two cases of occupational asthma caused by urea formaldehyde particle board, with positive hist~e bronchial challenge tests, but no increased RAST specific IgE antibodies Erected against formaldebyde human serf albumin conjugate. Read the entire page →
From page 24... ... Means of control have included technical and regulatory procedures (WHO/EURO, 1991~; educational control methods have been r~co~ended also. TABLE 3 Formaldehyde Sources With Usual Range of Related Concentrations Indoors Primary: Particle/ Press Board, Plywood (resin) Read the entire page →
From page 25... ... I. ~4 C=~o~ D~oo of Mosses Ed ~os~e-Resp~o Imps _ Ewe_ Dome ~ ~ (mamma) Read the entire page →
From page 26... ... 1987. Heterogeneity of mast cells in the tissues of the respiratory tract and other organ systems. Read the entire page →
From page 27... ... 1982. Occupational asthma caused by cedar urea formaldehyde particle board. Read the entire page →
From page 28... ... cell colony stimulating activities derived from human nasal polyp epithelial scrapings are T ceD-dependent. J Allergy Clin Immuno! Read the entire page →
From page 29... ... J Allergy Clin Immunol 73:259-266. Read the entire page →
From page 30... ... 1991. IL't and ILK inhibitory activity In the culture supernatants of alveolar macrophages from patients with interstitial lung diseases. Read the entire page →
From page 31... ... 1986. Basophilic cell progenitors, nasal metachromatic cells and peripheral blood basophils in ragweed allergic rhinitis. Read the entire page →
From page 32... ... J Allergy Clin Immunol 70(~) Read the entire page →
From page 33... ... Arch Environ Health 30:574577. Shins, C., M Read the entire page →
From page 34... ... World Health Organization Regional Office for Europe, Environ Health WHO/EURO. Read the entire page →

From page 13...

... Ideation of the andgen/aDergen in an individual previously sensitized leads to an Serge reaction, such as rbinitis or conjunctivitis. If the son is se~dzed, as in allergic contact dermatitis, then contact will cause an oedematous response and/or a rash.

Key Concepts: Chemical Sensitization Pages 13-34

Key Concepts: Chemical Sensitization
Pages 13-34