Putting Biotechnology to Work Bioprocess Engineering (1992) / Chapter Skim
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Executive Summary
Executive Summary
Pages 1-8
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Although the United States has nurtured the discovery phase of biotechnology, it has not been aggressive in developing bioprocess engineering. BIOPROCESS ENGINEERING AND GLOBAL COMPETITIVENESS The importance of engineering capability in achieving and maintaining global competitiveness is compelling; witness the growth of the pharmaceutical industry after the development of penicillin production during World War II and of the computer and electronics industry after the discovery of the transistor.
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The participation of the United States in the expanding bioproducts markets will necessitate world-class bioprocess engineering. Comparison of the global competitive position of the United States with that of other technologically advanced nations in biotechnology and bioprocess engineering reveals that · The United States continues to be the world leader in basic health science and life-science elements of biotechnology.
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Innovative bioprocess engineering in the manufacture of these products can lead to improvements in product recovery, product purity, process safety, and reduced manufacturing and quality-control costs. The need for such process innovation will intensify as patent protection for these products expires, global competition for international markets increases, and regulatory procedures that would otherwise slow introduction of new bioprocess technologies are streamlined.
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· Enhance biological and biochemical technology for increasing the efficiency of protein folding and improving the expression of recombinant proteins. For specialty bioproducts and industrial chemicals, key needs are to · Develop separation and purification technologies that are specially adapted to the recovery of products from dilute aqueous streams characteristic of materials derived from microbial fermentation, plant cell culture, or whole plant material.
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Sustained funding by the federal government is essential to the success of research and education programs for training bioprocess engineers, as is the participation of industry in planning, training, and supply of physical and financial resources. The ability of the United States to sustain a dominant global position in biotechnology lies in developing a strong resource base for bioprocess engineering and bioproduct manufacturing and maintaining its primacy in basic life-science research.
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Human-Resources Development The committee recommends a major commitment to developing the human-resources base through funding of research programs in universities, continuing-education programs, and research directed toward industrial problems (applied-engineering research) by the cognizant government agencies, including the National Science Foundation (NSF)
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Teaching laboratories for bioprocess engineering should be upgraded so that they can provide a high-quality training experience for a larger number of students. Competitive-Grants Program The committee recommends that research funding be allocated to topics listed in this report through a competitive-grants program for bioprocesses in the manufacture of biopharmaceuticals and other bioproducts that cover a wide range of biological, chemical, and engineering disciplines.
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From page 8... ...
Bioprocessing for Cleanup of Environmental Hazards The committee recommends an analysis of the costs of biological treatment compared with other technologies. Bioremediation promises lower costs than other types of technology for cleaning up certain environmental hazards.
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