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Issues in Risk Assessment (1993) / Chapter Skim
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2.1 Measures of Carcinogenic Potency
Pages 113-115

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From page 113...
... . In this paper, we examine these and other issues involved in the use of carcinogen bioassay data for risk assessment purposes.
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From page 114...
... Thus, the TD50 is the dose for which the extra risk is equal to 50% or, equivalently, the dose at which the proportion of tumor-free animals is reduced by one-half. The TD50 may be estimated on the basis of tumor response rates observed in laboratory studies involving a series of increasing dose levels.
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From page 115...
... have been criticized on the grounds that they require extrapolation of data well below the experimentally observable tumor response range. The TD50, on the other hand, does not require low dose extrapolation, but does not lead directly to estimates of risk at environmental exposure levels.
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Key Terms

  • extra risk
  • carcinogen bioassay
  • experimental dose
  • low dose
  • bioassay data

  • dose range
  • linear term
  • tumor response
  • risk associated
  • dose risk

  • require low
  • print version
  • observable tumor
  • risk based
  • studies involving

  • interspecies correlation
  • maximum dose
  • risk estimation
  • primary component
  • carcinogenic risk

  • lead directly
  • assessment purposes
  • tolerated dose
  • benchmmark dose
  • require extrapolation

  • scheme proposed
  • low doses
  • maximum tolerated
  • essentially linear
  • multifactor ranking


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