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Issues in Risk Assessment (1993) / Chapter Skim
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2.4 Classification of Carcinogens
Pages 119-120

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From page 119...
... The distribution of true TD50s may be determined using the shrinkage estimators described in annex B This technique adjusts for overdispersion by ''shrinking" each estimated TD50 towards the mean TD50 on a logarithmic scale, using a shrinkage factor determined by the relative magnitude of the variation within and between experiments (see annex B for details)
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From page 120...
... Please use the print version of this publication as the authoritative version for attribution.APPENDIX F FIGURE 1b Variation in carcinogenic potency of 191 chemical carcinogens selected from the CPDB.
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Key Terms

  • carcinogenic potency
  • nonzero dose
  • national toxicology
  • estimators described
  • carcinogens tested

  • determined using
  • print version
  • logarithmic scale
  • shrinkage factor
  • fitted lognormal

  • carcinogens selected
  • single species
  • recently examined
  • weibull model
  • single tissue

  • lognormal distribution
  • shrinkage estimators
  • dose level
  • toxicology program
  • authoritative version

  • untested chemical
  • shrinkage estimator
  • animal carcinogens
  • human carcinogens
  • relative magnitude

  • carcinogens based
  • factor determined
  • lower quantile
  • regulatory attention
  • detailed discussion


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