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Issues in Risk Assessment (1993) / Chapter Skim
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3.1 Empirical Correlations
Pages 121-124

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From page 121...
... also showed that genotoxic carcinogens that demonstrated mutagenic effects in the Salmonella assay were, on average, more potent than nongenotoxic carcinogens that tested negative in Salmonella. Human carcinogens also appear to be predominantly genotoxic (Shelby et al., 1988; Bartsch & Malaveille, 1989)
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From page 122...
... Please use the print version of this publication as the authoritative version for attribution.APPENDIX F FIGURE 2a Association between carcinogenic potency and maximum tolerated dose.
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From page 123...
... Please use the print version of this publication as the authoritative version for attribution.APPENDIX F FIGURE 2b Association between carcinogenic potency and maximum tolerated dose.
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From page 124...
... Please use the print version of this publication as the authoritative version for attribution.APPENDIX F FIGURE 2c Association between carcinogenic potency and maximum tolerated dose.
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Key Terms

  • tolerated dose
  • maximum tolerated
  • potent rodent
  • human carcinogens
  • carcinogens discussed

  • human carcinogen
  • print version
  • chemical carcinogens
  • reanalyzed data
  • strong association

  • apparently nongenotoxic
  • nongenotoxic carcinogens
  • demonstrated mutagenic
  • salmonella assay
  • predominantly genotoxic

  • mutagenic effects
  • tested negative
  • rodent carcinogen
  • authoritative version
  • rodent carcinogens

  • potent carcinogens
  • genotoxic carcinogens
  • rodent lifetime
  • strong positive
  • human carcinogenicity

  • marked correlation
  • animals developing
  • carcinogens evaluated
  • multistage model
  • crude proportion


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