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Issues in Risk Assessment (1993) / Chapter Skim
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3.3 Analytical Correlations
Pages 126-127

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From page 126...
... It follows that since cancer potency values are constrained to lie within a narrow range determined by the MTD, the wide variation in MTDs for chemical carcinogens necessarily induces a high correlation between cancer potency and the MTD. 3.3 Analytical Correlations The correlation between the MTD and the TD50 may be also be established using analytical arguments, details of which are provided in annex D
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From page 127...
... Please use the print version of this publication as the authoritative version for attribution.APPENDIX F FIGURE 3 Distribution of MTDs for 191 chemical carcinogens selected from the CPDB.
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Key Terms

  • chemical carcinogens
  • upper limit
  • background incidences
  • assumed background
  • carcinogens necessarily

  • truncated upper
  • print version
  • rarely observed
  • range determined
  • carcinogenic potency

  • wide variation
  • narrow range
  • carcinogens selected
  • potency varies
  • little practical

  • potency values
  • necessarily induces
  • cancer potency
  • authoritative version
  • consider tumor

  • carcinogens follows
  • established using
  • tumor counts
  • correlation coefficient
  • tumor incidence

  • correlation depends
  • experimental designs
  • approximate normality
  • using analytical
  • analytical correlations


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