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Issues in Risk Assessment (1993) / Chapter Skim
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3.4 Model Dependency
Pages 128-129

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From page 128...
... (1990) argue that this limits the range of estimates of potency, and so artificially increases the correlation between the estimates of potency and the TABLE 1 Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose as a Function of Sample Sizea Correlationc Sample Size n Range of Experimental Range of Outcomes, x/n Potency Estimates (upper limit ÷ lower limit)
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From page 129...
... (1988) demonstrate that an appreciable portion of the National Cancer Institute/ National Toxicology Program bioassays exhibit downward curvature (k < 1)
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Key Terms

  • carcinogenic potency
  • downward curvature
  • national toxicology
  • larger sample
  • additional variation

  • upward curvature
  • bioassays exhibit
  • exhibit downward
  • sample sizea
  • model includes

  • print version
  • range determined
  • linear restraints
  • added risk
  • relationship provides

  • narrow range
  • permits additional
  • allowable range
  • suggest relaxing
  • potency estimates

  • program bioassays
  • model limits
  • toxicology program
  • linear regression
  • maximum tolerated

  • sample sizes
  • sample size
  • authoritative version
  • correlationc sample
  • stage model


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