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Issues in Risk Assessment (1993) / Chapter Skim
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4.1 Predictions Based on the MDT
Pages 131-131

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From page 131...
... The authors suggested that this is consistent with the hypothesis that carcinogenic effects observed at the MTD are mediated to a certain extent by toxicity, and that the larger variability exhibited by genotoxic carcinogens is because of their ability to induce carcinogenic effects by direct damage to genetic material. This does not imply that toxicity does not play a role in the induction of tumors by mutagenic chemicals; rather it is the inability of nongenotoxic agents to interact directly with DNA that leads to this difference.
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Key Terms

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  • fitted regression

  • salmonella strains
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  • nongenotoxic carcinogens
  • direct damage
  • larger variability
  • various salmonella
  • genetic material

  • genotoxic potency
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  • nongenotoxic agents
  • regression line
  • linear regression

  • random error
  • mutagenic potency
  • regression model
  • mutagenic chemicals
  • estimated using

  • carcinogens relative
  • significant differences
  • authoritative version
  • interact directly
  • normally distributed


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