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Issues in Risk Assessment (1993) / Chapter Skim
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6. INTERSPECIES EXTRAPOLATION
Pages 140-140

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From page 140...
... Given an upper bound on the low dose slope β, the corresponding 10-6 RSD is simply 10-6/β. TABLE 4 Regression of Upper Bounds on Low Dose Slopes on the Maximum Tolerated Dosea Regression Parameter Extrapolation Method Multistage Model Model-Free Extrapolation Intercept ± SE 0.01 ± 0.05 0.11 ± 0.04 Slope ± SE -1.05 ± 0.03 -1.07 ± 0.02 Correlation 0.944 0.961 Root Mean Square (σ)
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Key Terms

  • x mdt
  • dose slope
  • regression parameter
  • slope encompass
  • species share

  • lower limit
  • bupper limit
  • common physiological
  • upper bounds
  • mammalian species

  • log slope
  • root mean
  • interspecies extrapolation
  • quantitative interspecies
  • simple linear

  • extrapolation method
  • prediction intervals
  • upper bound
  • dose slopes
  • log mdt

  • heat loss
  • linear regression
  • allometric relationships
  • physiological characteristics
  • physiological parameters

  • somewhat similar
  • allometric equations
  • authoritative version
  • differences exist
  • print version


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