Issues in Risk Assessment (1993) / Chapter Skim
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6.1 Extrapolation from Rats to Mice
6.1 Extrapolation from Rats to Mice
Pages 141-143
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From page 141... ...
Using either dose metric, the mean carcinogenic potency of these chemicals in rats and mice agree to within a factor of about two-fold. The ratio R of the TD50 values for rats and mice were approximately lognormally distributed, with log10R exhibiting a standard deviation of 0.82; this corresponds to a multiplicative factor of 100.82 ≈ 7-fold.
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From page 142... ...
Without the restriction of tumors at the same sex and site in both species, the geometric mean of the ratio of the minimum RSDs of rats to mice was 1.38 with a standard deviation of loge ratios of 0.78. It appears that relative potencies for rats and mice are generally within a multiplicative factor of 100-fold for rodent carcinogens.
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From page 143... ...
This investigation demonstrated that the observed correlation between carcinogenic potency and the MTD could, under certain conditions, produce a correlation which is purely artifactual. However, by comparison with actual bioassay data it was concluded that the observed correlation cannot be an artifact of constraints on the data and therefore must have some biological basis.
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