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Issues in Risk Assessment (1993) / Chapter Skim
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6.2 Extrapolation from Rodents to Humans
Pages 144-145

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From page 144...
... Several alternative methods of analyzing the animal bioassays were investigated, including the choice of the interspecies dose scaling factor, benign and malignant versus malignant tumors only, and separate versus average results across studies. Most of the methods yielded animal TD25s, that were significantly correlated with human TD25s, with rank correlation coefficients ranging up to 0.9.
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From page 145...
... Please use the print version of this publication as the authoritative version for attribution.APPENDIX F FIGURE 5 Association between carcinogenic potency in rats and mice.
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Key Terms

  • animal data
  • potency rankings
  • epidemiological studies
  • malignant tumors
  • dose scaling

  • cancer risks
  • average results
  • human epidemiological
  • print version
  • versus malignant

  • separate versus
  • scaling factor
  • predict potency
  • humans based
  • error associated

  • risks based
  • malignant versus
  • using animal
  • evaluated predictions
  • quantitative prediction

  • obtained estimates
  • human carcinogenic
  • response data
  • versus average
  • authoritative version

  • yielded animal
  • animal carcinogenesis
  • potency values
  • animal bioassays
  • interspecies dose


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