Issues in Risk Assessment (1993) / Chapter Skim
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7. CONCLUSIONS
7. CONCLUSIONS
Pages 146-148
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From page 146... ...
Empirical evidence indicates that measures of carcinogenic risk at low doses, such as the value of q1 in the linearized multistage model, are also correlated with the MTD, suggesting that preliminary estimates of low dose cancer risk
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From page 147... ...
While toxic, mutagenic, and carcinogenic effects do share certain characteristics in common, each of these processes is sufficiently complex to cast doubt on a causal relationship between simple measures of toxic and mutagenic potential and carcinogenic potency. Statistically, correlations between the MDT and the TD50 occur as a result of the narrow range of possible potency values within a single experiment in relation to the wide variation observed in the potency of chemical carcinogens.
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From page 148... ...
does represent the smallest possible linearized upper bound on low dose risk based on the multistage model which is consistent with the experimental data. The TD50, moreover, represents a dose which has been shown, often without the need for extrapolation outside of the observable response range, to reduce the proportion of tumor-free animals by one-half.
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