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Issues in Risk Assessment (1993) / Chapter Skim
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8. ACKNOWLEDGEMENTS
Pages 149-149

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From page 149...
... Quantitative interspecies extrapolation of carcinogenic potency is therefore done under the presumption that the agent in question will be effective in both species involved. If progress in carcinogenic risk assessment based on bioassay data is to be made, it seems that additional information beyond that contained in traditional experiments is required.
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Key Terms

  • carcinogenic potency
  • interspecies extrapolation
  • low dose
  • species concordance
  • cell turnover

  • urinary bladder
  • biologically based
  • considerations suggest
  • neoplastic conversion
  • provide improved

  • based pharmacokinetic
  • bioassay data
  • sensitive indicators
  • concordance depends
  • sufficient increase

  • improved tissue
  • rat liver
  • cancer risk
  • improved interspecies
  • quantitative interspecies

  • dna damage
  • rodents provides
  • dat produces
  • pharmacokinetic models
  • carcinogenic risk

  • assessment based
  • damage suspected
  • risk estimates
  • physiologically based
  • based approach


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