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Issues in Risk Assessment (1993) / Chapter Skim
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ANNEX A: MAXIMUM LIKELIHOOD METHODS FOR FITTING THE WEIBULL MODEL
Pages 160-161

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From page 160...
... Please use the print version of this publication as the authoritative version for attribution. ANNEX A: MAXIMUM LIKELIHOOD METHODS FOR FITTING THE WEIBULL MODEL Suppose that the probability P(d)
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From page 161...
... For the 122 data sets for which mle's could be obtained, an adjusted measure of carcinogenic potency given by was calculated using the factor f2/k discussed in annex C This effectively adjusts all TD50 values to a two year standard rodent lifespan.
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Key Terms

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  • strictly increasing
  • data sets

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  • unknown model
  • likelihood function
  • rodent lifespan
  • upward curvature

  • response curves
  • unpleasant conclusion
  • linear approximation
  • dose levels
  • carcinogenic potency

  • effectively adjusts
  • estimation methods
  • finite mle
  • intuitively reasonable
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