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Issues in Risk Assessment (1993) / Chapter Skim
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ANNEX B. SHRINKAGE ESTIMATORS OF THE DISTRIBUTION OF CARCINOGENIC POTENCY
Pages 162-163

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From page 162...
... . Rather than discard the 69 data sets for which mle's could not be obtained, we chose to fit a Weibull model to each of these data sets using a fixed value of the shape parameter k.
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From page 163...
... . The shrinkage estimator of µ i is given by where represents an estimator of the intrastudy correlation, is an estimator of the overall mean of the log potency distribution, and is designed to protect against overadjustment for overdispersion.
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Key Terms

  • carcinogenic potency
  • shrinkage estimators
  • estimation error
  • upward curvature
  • provides useful

  • fixed value
  • print version
  • chemical carcinogens
  • empirical bayes
  • using empirical

  • weibull model
  • single dose
  • sets exhibiting
  • sets using
  • eliminated using

  • bayes shrinkage
  • estimated potency
  • potency values
  • exhibiting downward
  • downward curvature

  • data sets
  • authoritative version
  • normally distributed
  • estimated using
  • log potency

  • specific chemical
  • obtained using
  • overall shape
  • using risk
  • shrinkage estimator


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